No- there has been no report or evidence to show that silver creates any resistance or immunity in the pathogens which are killed by it. Properly made, in my experience, there is no argyria (bluing of the skin) or side effects from a pure silver solution <30ppm (not above 30ppm, to prevent clumping or agglutination of silver ions, which create a less effective solution by increasing the particle size, thereby decreasing penetration power). The mechanisms by which silver kills pathogens are much like suffocation, or a decrease in cell respiration, leading to death. This is not something towards resistance may be built.
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